Best = SharePoint Server 2010 + Office 2010
Better = SharePoint Server 2010 + Office 2007
Good = SharePoint Server 2010 + Office 2003

You don’t HAVE to have Office at all if you don’t want – SharePoint Server will do LOTS of cool stuff without the client at all – it’s just that the ‘better together’ story is so strong with the integration points.
For SharePoint Designer:

Compatible = SharePoint Server 2010 + SharePoint Designer 2010
NOT Compatible = SharePoint Server 2010 + SharePoint Designer 2007 !!

Compatible = SharePoint Server 2007 + SharePoint Designer 2007
NOT Compatible = SharePoint Server 2007 + SharePoint Designer 2010 !!

Hi ! now a days i am trying to develop a website using SharePoint 2010 , so  I have started my work from SharePoint Central Admin ,when i clicked on “Manage Web Application.”  I saw  ”New” option is in disable mode (grayed out).

Solution:

(Follow the Steps )

Step-1: Copy the URL from Address Bar.(Don’t try to write this url(Shown in Image) the URL should be yours)

Step-2:Goto Option>Internet options >Select Security Tab>Select Local Intranet >Click on Site

Step-3:Paste The URL In TextBox And Click On Add >Close >Apply >ok

Step-4:Start>Sharepoint central Administrator >Right click >Open as admin. >ok

Step-5 > Select Manage web Applications Option

Step-6 >Congratulation !!! Now Everything is working Fine .